Gene information
Official symbol PFN1
Official full name profilin 1
Gene type protein-coding gene
Chromosome17p13.2
Gene familyProfilins
Resources
Entrez Gene 5216
HGNC HGNC:8881
Ensembl ENSG00000108518
Vega OTTHUMG00000099396
UCSC uc002gaa.5
GO terms: 66 records
GO Description Category LogP Number of genes Detail
GO:0001838 embryonic epithelial tube formation GO Biological Processes -6.74209917 20 More
GO:0001841 neural tube formation GO Biological Processes -5.20987525 16 More
GO:0001843 neural tube closure GO Biological Processes -4.06290305 13 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0003779 actin binding GO Molecular Functions -9.68875312 26 More
GO:0003785 actin monomer binding GO Molecular Functions -3.27686977 4 More
GO:0005543 phospholipid binding GO Molecular Functions -6.61792344 45 More
GO:0005925 focal adhesion GO Cellular Components -8.40302345 46 More
GO:0005938 cell cortex GO Cellular Components -2.49954036 24 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010639 negative regulation of organelle organization GO Biological Processes -2.25995266 25 More
GO:0014020 primary neural tube formation GO Biological Processes -5.01152693 15 More
GO:0016331 morphogenesis of embryonic epithelium GO Biological Processes -7.49308957 23 More
GO:0021700 developmental maturation GO Biological Processes -12.5205714 23 More
GO:0021915 neural tube development GO Biological Processes -7.57225811 24 More
GO:0030029 actin filament-based process GO Biological Processes -9.62516039 61 More
GO:0030036 actin cytoskeleton organization GO Biological Processes -5.67075265 47 More
GO:0030055 cell-substrate junction GO Cellular Components -9.04790297 48 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031346 positive regulation of cell projection organization GO Biological Processes -6.78114948 37 More
GO:0031647 regulation of protein stability GO Biological Processes -2.93350742 12 More
GO:0032231 regulation of actin filament bundle assembly GO Biological Processes -4.42971140 15 More
GO:0032233 positive regulation of actin filament bundle assembly GO Biological Processes -4.83092272 7 More
GO:0032272 negative regulation of protein polymerization GO Biological Processes -1.87564725 8 More
GO:0032535 regulation of cellular component size GO Biological Processes -4.60941253 33 More
GO:0032781 positive regulation of ATP-dependent activity GO Biological Processes -1.67750771 3 More
GO:0032956 regulation of actin cytoskeleton organization GO Biological Processes -4.25470878 32 More
GO:0032970 regulation of actin filament-based process GO Biological Processes -7.72273150 43 More
GO:0034330 cell junction organization GO Biological Processes -7.96624809 49 More
GO:0035148 tube formation GO Biological Processes -7.32029616 23 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0043009 chordate embryonic development GO Biological Processes -11.8113315 68 More
GO:0043462 regulation of ATP-dependent activity GO Biological Processes -4.31702711 7 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0050808 synapse organization GO Biological Processes -6.17744712 32 More
GO:0050821 protein stabilization GO Biological Processes -2.69690139 9 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051492 regulation of stress fiber assembly GO Biological Processes -3.91249954 13 More
GO:0051493 regulation of cytoskeleton organization GO Biological Processes -3.52271067 40 More
GO:0051495 positive regulation of cytoskeleton organization GO Biological Processes -3.67944181 20 More
GO:0060074 synapse maturation GO Biological Processes -3.89921208 5 More
GO:0060491 regulation of cell projection assembly GO Biological Processes -2.36338574 17 More
GO:0060562 epithelial tube morphogenesis GO Biological Processes -17.7630248 53 More
GO:0060606 tube closure GO Biological Processes -4.01197458 13 More
GO:0072175 epithelial tube formation GO Biological Processes -6.28242122 20 More
GO:0072562 blood microparticle GO Cellular Components -39.0217600 39 More
GO:0098978 glutamatergic synapse GO Cellular Components -4.83590061 31 More
GO:0110020 regulation of actomyosin structure organization GO Biological Processes -4.68299748 15 More
GO:0110053 regulation of actin filament organization GO Biological Processes -3.93783734 26 More
GO:0120032 regulation of plasma membrane bounded cell projection assembly GO Biological Processes -2.40785708 17 More
GO:0120034 positive regulation of plasma membrane bounded cell projection assembly GO Biological Processes -1.88939040 5 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:1902903 regulation of supramolecular fiber organization GO Biological Processes -5.63791156 37 More
GO:1902904 negative regulation of supramolecular fiber organization GO Biological Processes -2.83678359 16 More
GO:1902905 positive regulation of supramolecular fiber organization GO Biological Processes -5.32876142 22 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 5 records
KEGG Description Category LogP Number of genes Detail
hsa04015 Rap1 signaling pathway KEGG Pathway -8.52596130 17 More
hsa04810 Regulation of actin cytoskeleton KEGG Pathway -10.0068804 19 More
hsa05014 Amyotrophic lateral sclerosis KEGG Pathway -1.64954984 10 More
hsa05131 Shigellosis KEGG Pathway -5.26807538 14 More
hsa05132 Salmonella infection KEGG Pathway -7.42305681 17 More
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
profilin-1 proteomics medium predictor thrombosis[prognosis (bad)] acute ST elevation myocardial infarction Ramaiola I et al. Eur Heart J. 2015
profilin-1 proteomics time from symptom-onset to percutaneous coronary intervention[other] acute type 1 myocardial infarction Paszek E et al. Eur Rev Med Pharmacol Sci. 2020
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